International Psychogeriatrics
Volume 15, Supplement 1 - 2003

Prevention of White-Matter Lesions Through Control of Cerebrovascular Risk Factors
CHARLES DECARLI

ABSTRACT. Multiple epidemiological and brain imaging studies show a strong association between elevations in systolic blood pressure and lesions of cerebral white matter. The association between white-matter lesions and systolic blood pressure persists even if individuals are receiving treatment, suggesting that these individuals may be undertreated. In addition, these studies suggest that lesions of cerebral white matter may serve as markers for atherosclerotic vascular disease. Treatment strategies, therefore, should focus on early and aggressive management of elevated blood pressure, but definitions of elevated blood pressure may need to be revised downward to achieve best results.

KEYWORDS: Hypertension; leukoaraiosis; white-matter hyperintensities; atherosclerosis; magnetic resonance imaging; treatment